⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485008 | 0.89 | PDE10A (0.56) | — | |
| SCHEMBL2484904 | 0.88 | — | — | |
| SCHEMBL2485035 | 0.87 | — | — | |
| SCHEMBL2486496 | 0.84 | PDE10A (0.64) | — | |
| SCHEMBL2488283 | 0.84 | — | — | |
| SCHEMBL13685537 | 0.84 | — | — | |
| SCHEMBL3341572 | 0.84 | — | — | |
| SCHEMBL7904960 | 0.83 | HTR1A (0.60) | — | |
| SCHEMBL2486840 | 0.83 | PDE10A (0.61) | — | |
| SCHEMBL2483898 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376455-A1 | AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010077992-A1 | AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2010-07-08 | — | — | WO | disclosed |