Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.53 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 4/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | BCR | P11274 | 2/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389823 | 0.85 | NAMPT (0.52) | NAMPTSPRROCK2KDM1A | |
| SCHEMBL2390194 | 0.81 | NAMPT (0.54) | NAMPTSPRROCK2KDM1AHSD11B1 | |
| SCHEMBL2390745 | 0.81 | NAMPT (0.54) | NAMPTSPRROCK2KDM1AHSD11B1 | |
| SCHEMBL2388609 | 0.79 | NAMPT (0.51) | NAMPTSPRROCK2KDM1AHSD11B1 | |
| SCHEMBL2390029 | 0.78 | SPR (0.58) | NAMPTSPRROCK2KDM1AHSD11B1 | |
| SCHEMBL2393166 | 0.78 | NAMPT (0.62) | NAMPTSPRHSD11B1NPC1RAB9A | |
| SCHEMBL2390964 | 0.78 | NAMPT (0.53) | NAMPTSPRROCK2PARP14PARP10 | |
| SCHEMBL2390301 | 0.77 | NAMPT (0.57) | NAMPTSPRROCK2KDM1AHSD11B1 | |
| SCHEMBL2390098 | 0.77 | NAMPT (0.51) | NAMPTSPRROCK2PARP14PARP10 | |
| SCHEMBL2390814 | 0.76 | NAMPT (0.56) | NAMPTSPRROCK2KDM1AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2375904-A1 | BIARYL CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2011-10-19 | — | — | EP | claimed |
| WO-2010077624-A1 | BIARYL CARBOXAMIDES | MERCK SHARP & DOHME CORP. (US) | 2010-07-08 | — | — | WO | claimed |