Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAICS | P22234 | 5/20 | 0.37 |
| ▸ | CNR1 | P21554 | 7/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490109 | 1.00 | PAICS (0.37) | PAICSCNR1KDRHTR7ROCK2 | |
| SCHEMBL913398 | 0.94 | PAICS (0.34) | PAICSCNR1KDRHTR7ROCK2 | |
| SCHEMBL913397 | 0.94 | PAICS (0.34) | PAICSCNR1KDRHTR7ROCK2 | |
| SCHEMBL2492517 | 0.94 | PAICS (0.36) | PAICSKDRHTR7ROCK2ROCK1 | |
| SCHEMBL2492514 | 0.94 | PAICS (0.36) | PAICSKDRHTR7ROCK2ROCK1 | |
| SCHEMBL2491076 | 0.92 | LPAR1 (0.39) | PAICSCNR1LPAR1 | |
| Hydrochloric Acid SCHEMBL544756 | 0.91 | LPAR1 (0.38) | PAICSCNR1LPAR1 | |
| SCHEMBL914700 | 0.88 | PAICS (0.34) | PAICSKDRHTR7ROCK2ROCK1 | |
| SCHEMBL914701 | 0.88 | PAICS (0.34) | PAICSKDRHTR7ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL545149 | 0.88 | SLC6A9 (0.36) | PAICSKDRHTR7ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238110-B1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI SA (FR) | 2011-10-26 | — | — | EP | claimed |
| EP-2238110-B1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI SA (FR) | 2011-10-26 | — | — | EP | disclosed |