SCHEMBL24866228

SCHEMBL24866228

COc1cc(C#CC2CNC2)cc(OC)c1SNc1noc2cc(Cn3cccn3)cc(OC)c12

nearest known ligand 0.50

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KAT6A Q92794 20/20 0.50
▸ KAT7 O95251 19/20 0.50
▸ KAT6B Q8WYB5 13/20 0.50
▸ KAT5 Q92993 13/20 0.50
▸ KAT8 Q9H7Z6 13/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24866482 0.93 KAT6A (0.54) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL24866460 0.92 KAT6A (0.51) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL24866174 0.90 KAT6A (0.49) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL24866749 0.87 KAT7 (0.57) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL24866178 0.85 KAT7 (0.71) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL24866161 0.84 KAT7 (0.53) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL24866764 0.83 KAT7 (0.53) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL24866475 0.82 KAT6A (0.71) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL22817402 0.82 KAT7 (0.68) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL24866485 0.79 KAT7 (0.52) KAT6AKAT7KAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023280182-A1 COMPOUND SERVING AS KAT6 INHIBITOR 杭州英创医药科技有限公司 2023-01-12 — — WO disclosed
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