Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 14/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29809327 | 0.99 | TLR7 (0.47) | TLR7ADORA2AADORA2BTLR8 | |
| SCHEMBL567233 | 0.99 | TLR7 (0.47) | TLR7ADORA2AADORA2BTLR8 | |
| SCHEMBL2200726 | 0.89 | TLR7 (0.41) | TLR7ADORA2AADORA2B | |
| SCHEMBL10057869 | 0.89 | ADORA2A (0.37) | TLR7ADORA2AADORA2B | |
| SCHEMBL2199084 | 0.88 | TLR7 (0.37) | TLR7ADORA2AADORA2B | |
| SCHEMBL31124759 | 0.88 | ADORA2A (0.40) | TLR7ADORA2AADORA2B | |
| SCHEMBL2199802 | 0.87 | ADORA2A (0.43) | TLR7ADORA2AADORA2B | |
| SCHEMBL24733095 | 0.87 | TLR7 (0.49) | TLR7 | |
| SCHEMBL2199990 | 0.86 | ADORA2A (0.42) | TLR7ADORA2AADORA2B | |
| SCHEMBL31126573 | 0.86 | TLR7 (0.38) | TLR7ADORA2AADORA2BTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139894-B1 | 9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7) MODULATORS | ASTRAZENECA AB (SE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2041135-A1 | 8-OXOADENINE DERIVATIVES ACTING AS MODULATORS OF TLR7 | Astra Zeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008004948-A1 | 8-OXOADENINE DERIVATIVES ACTING AS MODULATORS OF TLR7 | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |