Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 5/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12197672 | 0.86 | CYP1A2 (0.39) | PDE2ALMNAHRH4HTR2CHTR2A | |
| SCHEMBL15954389 | 0.81 | PDE2A (0.43) | PDE2ALMNATP53HTTHTR2C | |
| SCHEMBL31574281 | 0.81 | PDE2A (0.43) | PDE2ALMNATP53HTTHTR2C | |
| SCHEMBL18588971 | 0.80 | PSEN1 (0.46) | PDE2ALMNATP53HTTHTR2C | |
| SCHEMBL10039364 | 0.80 | RECQL (0.36) | PDE2ALMNAHRH4HTR2ARECQL | |
| SCHEMBL30682753 | 0.80 | PSEN1 (0.46) | PDE2ALMNATP53HTTHTR2C | |
| SCHEMBL20238249 | 0.80 | PSEN1 (0.46) | PDE2ALMNATP53HTTHTR2C | |
| SCHEMBL706808 | 0.80 | PDE2A (0.60) | PDE2ALMNATP53HTTHTR2C | |
| SCHEMBL1761854 | 0.80 | PDE2A (0.60) | PDE2ALMNATP53HTTHTR2C | |
| SCHEMBL29668895 | 0.80 | PSEN1 (0.46) | PDE2ALMNATP53HTTHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023279986-A1 | SIX-MEMBERED ARYL OR HETEROARYL AMIDES, AND COMPOSITION AND USE THEREOF | 贝达药业股份有限公司 | 2023-01-12 | — | — | WO | disclosed |