SCHEMBL24869245

SCHEMBL24869245

CC(C)c1cnc(-n2nc(C#N)c(C#N)n2)c(Cl)c1

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ERBB2 P04626 1/20 0.33
MALT1 Q9UDY8 3/20 0.32
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17947393 0.79 ALDH1A1 (0.41) ERBB2KDM4EALDH1A1POLB
SCHEMBL21030633 0.78 MALT1 (0.44) MALT1
SCHEMBL24869251 0.70 HTR2C (0.33)
SCHEMBL16248222 0.69 P2RY12 (0.40) POLB
SCHEMBL21030732 0.68 NPC1 (0.35) MALT1ALDH1A1POLB
SCHEMBL24869545 0.68 HRH4 (0.33)
SCHEMBL14349216 0.68 P2RY12 (0.39) ALDH1A1POLB
SCHEMBL14116671 0.67 ERBB2 (0.37) ERBB2KDM4EALDH1A1POLB
SCHEMBL24869570 0.67 CCNT1 (0.32)
SCHEMBL14116670 0.66 EGLN2 (0.38) ERBB2KDM4EALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023279986-A1 SIX-MEMBERED ARYL OR HETEROARYL AMIDES, AND COMPOSITION AND USE THEREOF 贝达药业股份有限公司 2023-01-12 WO disclosed