Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KYAT1 | Q16773 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 9/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060308 | 1.00 | KYAT1 (0.52) | KYAT1GAALMNAMAPTALDH1A1 | |
| SCHEMBL1998080 | 1.00 | KYAT1 (0.52) | KYAT1GAALMNAMAPTALDH1A1 | |
| SCHEMBL5252880 | 0.87 | KYAT1 (0.67) | KYAT1GAALMNAMAPTALDH1A1 | |
| SCHEMBL5252876 | 0.87 | KYAT1 (0.67) | KYAT1GAALMNAMAPTALDH1A1 | |
| SCHEMBL31597961 | 0.87 | KYAT1 (0.67) | KYAT1GAALMNAMAPTALDH1A1 | |
| SCHEMBL6107763 | 0.87 | KYAT1 (0.67) | KYAT1GAALMNAMAPTALDH1A1 | |
| SCHEMBL11762275 | 0.86 | KYAT1 (0.50) | KYAT1GAALMNAMAPTALDH1A1 | |
| SCHEMBL11762267 | 0.86 | KYAT1 (0.50) | KYAT1GAALMNAMAPTALDH1A1 | |
| SCHEMBL25985823 | 0.86 | KYAT1 (0.50) | KYAT1GAALMNAMAPTALDH1A1 | |
| SCHEMBL16730435 | 0.86 | KYAT1 (0.50) | KYAT1GAALMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379531-A1 | PROCESSES FOR THE MANUFACTURE OF 3-{4-METHYL-5- [ (IR) -1- (2- (3-METHYLPHENYL) -2H-TETRAZOL-5-YL) -ETHOXY]-4H- [1,2, 4]TRIAZOL-3-YL} -PYRIDINE, 4-METHYL-3-METHYLTHIO-5- (3- PYRIDYL)-L,2,4-TRIAZOLE, AND (IR) -1- [2- (3-METHYLPHENYL) -2H- TETRAZOL-5-YL]ETHANOL | AstraZeneca AB (SE) | 2011-10-26 | — | — | EP | disclosed |