Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24873114 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL4109741 | 0.82 | HDAC3 (0.62) | SMN1; SMN2ALDH1A1GAAMAPTHDAC3 | |
| SCHEMBL7332230 | 0.82 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL4769824 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL21646851 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL13860786 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAALDH1A1L3MBTL1GAA | |
| SCHEMBL7337026 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL15514552 | 0.79 | HTT (0.55) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 | |
| SCHEMBL27805304 | 0.79 | HTT (0.52) | SMN1; SMN2LMNAHTTALDH1A1HDAC3 | |
| SCHEMBL8914641 | 0.79 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAHTTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230009608-A1 | GRK2 INHIBITORS AND USES THEREOF | SONATA THERAPEUTICS, INC. | 2023-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230009608-A1 | GRK2 INHIBITORS AND USES THEREOF | GRK2, GRK3, GRK1 | SMN1; SMN2 2194/4885LMNA 3887/4885HTT 1888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.