Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | BCL9 | O00512 | 7/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 7/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31258392 | 0.85 | NR1H2 (0.48) | GPR119BCL9CTNNB1NOTUM | |
| SCHEMBL24872972 | 0.85 | PPARA (0.54) | ALDH1A1KDM4EMEN1GAAHPGD | |
| SCHEMBL24873112 | 0.84 | BCL9 (0.46) | GPR119BCL9CTNNB1NOTUM | |
| SCHEMBL30609810 | 0.84 | BCL9 (0.46) | GPR119BCL9CTNNB1NOTUM | |
| SCHEMBL23124821 | 0.83 | NOTUM (0.59) | BCL9CTNNB1NOTUM | |
| SCHEMBL31258386 | 0.83 | NOTUM (0.59) | BCL9CTNNB1NOTUM | |
| SCHEMBL23124851 | 0.83 | NOTUM (0.59) | BCL9CTNNB1NOTUM | |
| SCHEMBL31258377 | 0.81 | BCL9 (0.49) | BCL9CTNNB1NOTUM | |
| SCHEMBL30609813 | 0.80 | MAP4K4 (0.47) | BCL9CTNNB1 | |
| SCHEMBL31258404 | 0.80 | FFAR4 (0.42) | ALDH1A1KDM4EMEN1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023077057-A1 | SMALL-MOLECULAR INHIBITORS FOR THE BETA-CATENIN/ B-CELL LYMPHOMA 9 PROTEIN-PROTEIN INTERACTION | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2023280177-A1 | SMALL MOLECULE COMPOUND TARGETING BCL9/β-CATENIN INTERACTION | 南通聚太生物科技有限公司 | 2023-01-12 | — | — | WO | disclosed |