SCHEMBL31258392

SCHEMBL31258392

CC(C)(C)OC(=O)C(C)(C)Oc1cccc(N2CCCC(C3CCCCC3)C2)c1

nearest known ligand 0.48

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.48
NR1H3 Q13133 1/20 0.48
BCL9 O00512 15/20 0.45
CTNNB1 P35222 15/20 0.45
GPR119 Q8TDV5 3/20 0.44
NOTUM Q6P988 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24873112 0.86 BCL9 (0.46) NR1H2NR1H3BCL9CTNNB1GPR119
SCHEMBL30609810 0.86 BCL9 (0.46) NR1H2NR1H3BCL9CTNNB1GPR119
SCHEMBL24873121 0.85 ALDH1A1 (0.44) BCL9CTNNB1GPR119NOTUM
SCHEMBL31258386 0.85 NOTUM (0.59) BCL9CTNNB1NOTUM
SCHEMBL23124821 0.85 NOTUM (0.59) BCL9CTNNB1NOTUM
SCHEMBL23124851 0.85 NOTUM (0.59) BCL9CTNNB1NOTUM
SCHEMBL31258377 0.83 BCL9 (0.49) BCL9CTNNB1NOTUM
SCHEMBL30609813 0.82 MAP4K4 (0.47) BCL9CTNNB1
SCHEMBL30093635 0.81 BCL9 (0.50) BCL9CTNNB1
SCHEMBL30361577 0.81 BCL9 (0.50) BCL9CTNNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240391896-A1 SMALL MOLECULE COMPOUND TARGETING BCL9/BETA-CATENIN INTERACTION Nantong Jutai Biotech Co., Ltd. (CN) 2024-11-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240391896-A1 SMALL MOLECULE COMPOUND TARGETING BCL9/BETA-CATENIN INTERACTION BCL9, BCL9L, BCL2L11 NR1H2 426/4885NR1H3 313/4885BCL9 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.