Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 10/20 | 0.69 |
| ▸ | CRBN | Q96SW2 | 10/20 | 0.69 |
| ▸ | KHK | P50053 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23538519 | 0.91 | CRBN (0.69) | DDB1CRBNKHKCHEK1AURKA | |
| SCHEMBL23538689 | 0.90 | DDB1 (0.68) | DDB1CRBNKHKHTR6 | |
| Hydrochloric Acid SCHEMBL28995428 | 0.89 | DDB1 (0.67) | DDB1CRBNKHKHTR6 | |
| SCHEMBL23538921 | 0.88 | DDB1 (0.63) | DDB1CRBNKHKMAPTKDM4E | |
| SCHEMBL38657472 | 0.87 | DDB1 (0.67) | DDB1CRBNKHKCHEK1AURKA | |
| Hydrochloric Acid SCHEMBL31554745 | 0.86 | DDB1 (0.66) | DDB1CRBNKHKCHEK1AURKA | |
| SCHEMBL30999010 | 0.86 | DDB1 (0.60) | DDB1CRBNMAPTMAPK1 | |
| SCHEMBL30726276 | 0.86 | DDB1 (0.60) | DDB1CRBNKHKHTT | |
| SCHEMBL23538922 | 0.86 | DDB1 (0.60) | DDB1CRBNKHKCHEK1AURKA | |
| SCHEMBL27073829 | 0.86 | DDB1 (0.60) | DDB1CRBNKHKHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283372-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | BIOGEN MA INC. (US) | 2023-01-12 | — | — | WO | disclosed |