Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 10/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 9/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12367685 | 0.82 | GAA (0.55) | GAACRBNDDB1IKZF3 | |
| SCHEMBL2176628 | 0.82 | GAA (0.55) | GAACRBNDDB1IKZF3 | |
| SCHEMBL7205713 | 0.78 | BTK (0.78) | BTKGAAKMT2AL3MBTL1KDM1A | |
| SCHEMBL7212396 | 0.78 | BTK (0.78) | BTKGAAKMT2AL3MBTL1KDM1A | |
| SCHEMBL14502820 | 0.78 | BTK (0.78) | BTKGAAKMT2AL3MBTL1KDM1A | |
| SCHEMBL7210932 | 0.78 | BTK (0.78) | BTKGAAKMT2AL3MBTL1KDM1A | |
| SCHEMBL31068584 | 0.77 | GAA (0.52) | BTKGAACRBNDDB1NFKB1 | |
| SCHEMBL30703620 | 0.74 | DDB1 (0.61) | CRBNDDB1L3MBTL1EPHX2 | |
| SCHEMBL31514889 | 0.73 | DDB1 (0.42) | BTKGAACRBNDDB1 | |
| SCHEMBL20737119 | 0.72 | BTK (0.69) | BTKGAAKMT2AL3MBTL1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283372-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | BIOGEN MA INC. (US) | 2023-01-12 | — | — | WO | disclosed |