⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethane SCHEMBL11330720 | 0.97 | MGAM (0.57) | — | |
| SCHEMBL875655 | 0.81 | — | — | |
| SCHEMBL4377852 | 0.77 | — | — | |
| SCHEMBL27677215 | 0.75 | MGAM (1.00) | — | |
| SCHEMBL449524 | 0.75 | MGAM (0.67) | — | |
| SCHEMBL1162 | 0.75 | — | — | |
| SCHEMBL609208 | 0.75 | MGAM (0.67) | — | |
| SCHEMBL27882971 | 0.74 | — | — | |
| SCHEMBL28040109 | 0.74 | — | — | |
| SCHEMBL31411205 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108395431-B | A kind of rutaecarpin split ADT-OH class H2S donor derivative and its preparation method and application | 沈阳药科大学 | 2019-09-20 | — | — | CN | claimed |
| CN-108191866-B | A kind of ADT-OH class H2S donor and rutaecarpin splicing object and its preparation method and application | 沈阳药科大学 | 2019-07-26 | — | — | CN | claimed |
| CN-108395431-A | A kind of rutaecarpin split ADT-OH classes H2S donor derivatives and its preparation method and application | 沈阳药科大学 | 2018-08-14 | — | — | CN | claimed |
| CN-108191866-A | A kind of ADT-OH classes H2S donors and rutaecarpin splicing object and its preparation method and application | 沈阳药科大学 | 2018-06-22 | — | — | CN | claimed |
| CN-106749405-A | A kind of imidazolyl heterocycle class double phosphinic acid compounds and preparation method thereof, application | 江苏省原子医学研究所 | 2017-05-31 | — | — | CN | claimed |
| CN-106749406-A | A kind of 2 alkyl substituted imidazole base double phosphinic acid compounds and preparation method thereof, application | 江苏省原子医学研究所 | 2017-05-31 | — | — | CN | claimed |
| CN-108395431-B | A kind of rutaecarpin split ADT-OH class H2S donor derivative and its preparation method and application | 沈阳药科大学 | 2019-09-20 | — | — | CN | disclosed |
| CN-108191866-B | A kind of ADT-OH class H2S donor and rutaecarpin splicing object and its preparation method and application | 沈阳药科大学 | 2019-07-26 | — | — | CN | disclosed |
| CN-106749405-B | A kind of imidazolyl heterocycle class double phosphinic acid compounds and preparation method thereof, application | 江苏省原子医学研究所 | 2019-07-16 | — | — | CN | disclosed |
| CN-106749406-B | A kind of 2- alkyl substituted imidazole base double phosphinic acid compounds and preparation method thereof, application | 江苏省原子医学研究所 | 2019-04-12 | — | — | CN | disclosed |
| CN-108395431-A | A kind of rutaecarpin split ADT-OH classes H2S donor derivatives and its preparation method and application | 沈阳药科大学 | 2018-08-14 | — | — | CN | disclosed |
| CN-108191866-A | A kind of ADT-OH classes H2S donors and rutaecarpin splicing object and its preparation method and application | 沈阳药科大学 | 2018-06-22 | — | — | CN | disclosed |
| CN-104768554-B | Triazol compound | 霍夫曼-拉罗奇有限公司 | 2018-04-17 | — | — | CN | disclosed |
| EP-2379521-B1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-22 | — | — | EP | disclosed |
| US-20130237547-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2013-09-12 | — | — | US | disclosed |
| US-8436041-B2 | Sulfamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-05-07 | — | — | US | disclosed |
| EP-2379521-A1 | SULFAMIDES AS TRPM8 MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010080397-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-15 | — | — | WO | disclosed |
| US-20100160337-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2010-06-24 | — | — | US | disclosed |
| US-6046337-A | Process for the preparation of a dihydropyridine derivative | EGIS GYOGYSZERGYAR RT. (HU) | 2000-04-04 | — | — | US | disclosed |