Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25066349 | 0.83 | MAPK13 (0.38) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL30913666 | 0.82 | MAPK13 (0.37) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL24876803 | 0.82 | MAPK13 (0.37) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL25066630 | 0.79 | MAPK13 (0.38) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL25066674 | 0.79 | MAPK13 (0.35) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL423714 | 0.74 | PDPK1 (0.41) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL30129971 | 0.73 | MAPK13 (0.32) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL24876410 | 0.73 | MAPK13 (0.32) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL24876409 | 0.71 | HTR2A (0.40) | KDM4ECYP1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL7134676 | 0.65 | MAPK13 (0.40) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283213-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION (US) | 2023-01-12 | — | — | WO | disclosed |