Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.40 |
| ▸ | HTR2C | P28335 | 6/20 | 0.40 |
| ▸ | HTR2B | P41595 | 6/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856232 | 0.83 | CMA1 (0.45) | HTR2AHTR2CHTR2BGPR84IMPDH2 | |
| SCHEMBL30130003 | 0.81 | HTR2A (0.40) | HTR2AHTR2CHTR2BGPR84IMPDH2 | |
| SCHEMBL13015287 | 0.79 | HTR2C (0.41) | HTR2AHTR2CHTR2BGPR84IMPDH2 | |
| SCHEMBL25066353 | 0.79 | HTR2A (0.38) | HTR2AHTR2CHTR2BGPR84IMPDH2 | |
| SCHEMBL5645566 | 0.73 | GPR84 (0.65) | HTR2AGPR84IMPDH2ALDH1A1DUSP3 | |
| SCHEMBL30958471 | 0.73 | GPR84 (0.65) | HTR2AGPR84IMPDH2ALDH1A1DUSP3 | |
| SCHEMBL24876118 | 0.73 | HTR2A (0.34) | HTR2AHTR2CHTR2BGPR84IMPDH2 | |
| SCHEMBL30129969 | 0.73 | HTR2A (0.34) | HTR2AHTR2CHTR2BGPR84IMPDH2 | |
| SCHEMBL24876402 | 0.71 | MAPK13 (0.37) | ALDH1A1MEN1KMT2ACYP1A2KDM4E | |
| SCHEMBL10209154 | 0.69 | PDE10A (0.41) | HTR2AGPR84IMPDH2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283213-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION (US) | 2023-01-12 | — | — | WO | disclosed |