Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.41 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20504631 | 0.84 | NOTUM (0.56) | NOTUMKDM4EALDH1A1MAPK1HDAC4 | |
| SCHEMBL28862451 | 0.81 | NOTUM (0.53) | NOTUMKDM4EALDH1A1MAPK1HDAC4 | |
| SCHEMBL7425143 | 0.80 | NOTUM (0.51) | NOTUMKDM4EALDH1A1MAPK1HDAC4 | |
| SCHEMBL14790213 | 0.80 | NOTUM (0.51) | NOTUMKDM4EALDH1A1MAPK1HDAC4 | |
| SCHEMBL24877481 | 0.79 | NOTUM (0.50) | NOTUMKDM4EALDH1A1MAPK1HDAC4 | |
| SCHEMBL4341894 | 0.78 | NOTUM (0.78) | NOTUMKDM4EALDH1A1MAPK1HDAC4 | |
| SCHEMBL22817092 | 0.78 | NOTUM (0.49) | NOTUMKDM4EALDH1A1MAPK1HDAC4 | |
| SCHEMBL22817096 | 0.76 | KDM4E (0.51) | NOTUMKDM4EALDH1A1MAPK1HDAC4 | |
| SCHEMBL26284835 | 0.75 | HRH3 (0.50) | NOTUMKDM4EALDH1A1MAPK1HDAC4 | |
| SCHEMBL30872608 | 0.75 | NOTUM (0.53) | NOTUMKDM4EALDH1A1MAPK1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283425-A1 | ARYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT MODULATE IKZF2 | Plexium, Inc. (US) | 2023-01-12 | — | — | WO | disclosed |