Sugi Predict

Sugi Predict / Compounds / SCHEMBL24878285

SCHEMBL24878285

SCHEMBL24878285

Cc1c(Cl)cccc1N1CCN(C(=O)Cn2nc(C(=O)N3CCC(OCCO)CC3)c3c2CCC(F)C3)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IDO1 P14902 3/20 0.47
▸ LMNA P02545 3/20 0.39
▸ MAPT P10636 3/20 0.39
▸ PKM P14618 2/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ GAA P10253 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ NPSR1 Q6W5P4 1/20 0.39
▸ ALOX15 P16050 2/20 0.38
▸ ADAMTS5 Q9UNA0 4/20 0.37
▸ TP53 P04637 1/20 0.36
▸ ADAM17 P78536 2/20 0.36
▸ KDM4E B2RXH2 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ CNR2 P34972 1/20 0.34
▸ CXCR3 P49682 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24878514 0.89 IDO1 (0.50) IDO1LMNAMAPTPKMALDH1A1
SCHEMBL21995963 0.89 IDO1 (0.53) IDO1LMNAMAPTPKMALDH1A1
SCHEMBL21995995 0.85 IDO1 (0.50) IDO1LMNAMAPTPKMALDH1A1
SCHEMBL21995976 0.85 IDO1 (0.58) IDO1LMNAMAPTPKMALDH1A1
SCHEMBL30129121 0.85 IDO1 (0.51) IDO1LMNAMAPTPKMALDH1A1
SCHEMBL24878441 0.85 IDO1 (0.51) IDO1LMNAMAPTPKMALDH1A1
SCHEMBL30128902 0.85 IDO1 (0.51) IDO1LMNAMAPTPKMALDH1A1
SCHEMBL24878113 0.84 IDO1 (0.66) IDO1LMNAMAPTPKMALDH1A1
SCHEMBL24878355 0.84 IDO1 (0.66) IDO1LMNAMAPTPKMALDH1A1
SCHEMBL21995946 0.84 IDO1 (0.48) IDO1LMNAMAPTPKMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3886845-B1 NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2, 3-DIOXYGENASE (IDO) INHIBITORS MERCK SHARP & DOHME LLC (US) 2024-09-04 — — EP claimed
US-12264134-B2 Substituted piperazine amide compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors MERCK SHARP & DOHME LLC (US) 2025-04-01 — — US disclosed
US-20230008022-A1 NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS MERCK SHARP & DOHME CORP. (US) 2023-01-12 — — US disclosed
US-20230008022-A1 NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS MERCK SHARP & DOHME CORP. (US) 2023-01-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230008022-A1 NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS IDO1, IDO2, KYNU IDO1 1/4885LMNA 4773/4885MAPT 2271/4885
US-12264134-B2 Substituted piperazine amide compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors IDO1, IDO2, AADAC IDO1 1/4885LMNA 4655/4885MAPT 2376/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.