Sugi Predict

Sugi Predict / Compounds / SCHEMBL24878618

SCHEMBL24878618

SCHEMBL24878618

Cc1cccc(N2CCN(C(=O)Cn3nc(C(=O)N4CC[C@H](CO)C4)c4c3CCC4)CC2)c1C

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ IDO1 P14902 2/20 0.56
▸ ALOX15 P16050 2/20 0.46
▸ MAPT P10636 6/20 0.46
▸ KDM4E B2RXH2 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.46
▸ HSD17B10 Q99714 1/20 0.46
▸ MEN1 O00255 5/20 0.44
▸ KMT2A Q03164 5/20 0.44
▸ LMNA P02545 4/20 0.44
▸ HTT P42858 2/20 0.44
▸ RAB9A P51151 2/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ TSHR P16473 2/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ TP53 P04637 2/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24878662 0.96 IDO1 (0.54) IDO1ALOX15MAPTKDM4EALDH1A1
SCHEMBL24878635 0.95 IDO1 (0.54) IDO1ALOX15MAPTKDM4EALDH1A1
SCHEMBL24877947 0.94 IDO1 (0.55) IDO1ALOX15MAPTKDM4EALDH1A1
SCHEMBL22054269 0.90 IDO1 (0.52) IDO1ALOX15MAPTKDM4EALDH1A1
SCHEMBL30128817 0.90 IDO1 (0.60) IDO1ALOX15MAPTKDM4EALDH1A1
SCHEMBL24878481 0.89 IDO1 (0.53) IDO1ALOX15MAPTKDM4EALDH1A1
SCHEMBL24878457 0.89 IDO1 (0.63) IDO1ALOX15MAPTKDM4EALDH1A1
SCHEMBL24877917 0.89 IDO1 (0.61) IDO1ALOX15MAPTKDM4EALDH1A1
SCHEMBL24878105 0.88 IDO1 (0.57) IDO1ALOX15MAPTKDM4EALDH1A1
SCHEMBL30129298 0.88 IDO1 (0.57) IDO1ALOX15MAPTKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3886845-B1 NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2, 3-DIOXYGENASE (IDO) INHIBITORS MERCK SHARP & DOHME LLC (US) 2024-09-04 — — EP claimed
US-12264134-B2 Substituted piperazine amide compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors MERCK SHARP & DOHME LLC (US) 2025-04-01 — — US disclosed
US-20230008022-A1 NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS MERCK SHARP & DOHME CORP. (US) 2023-01-12 — — US disclosed
US-20230008022-A1 NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS MERCK SHARP & DOHME CORP. (US) 2023-01-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230008022-A1 NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS IDO1, IDO2, KYNU IDO1 1/4885ALOX15 633/4885MAPT 2271/4885
US-12264134-B2 Substituted piperazine amide compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors IDO1, IDO2, AADAC IDO1 1/4885ALOX15 859/4885MAPT 2376/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.