SCHEMBL2487932

SCHEMBL2487932

CN(C)c1ccc(C(N)=Cc2ccccc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RELA Q04206 1/20 0.53
MAPT P10636 8/20 0.53
KMT2A Q03164 8/20 0.53
RAB9A P51151 5/20 0.53
NPC1 O15118 3/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
CASP3 P42574 1/20 0.53
CYP1B1 Q16678 1/20 0.53
SENP8 Q96LD8 1/20 0.53
SENP7 Q9BQF6 1/20 0.53
SENP6 Q9GZR1 1/20 0.53
ALDH1A1 P00352 9/20 0.51
MAPK1 P28482 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
MEN1 O00255 5/20 0.50
HPGD P15428 3/20 0.50
LMNA P02545 2/20 0.49
GAA P10253 1/20 0.49
GFER P55789 1/20 0.47
CHIA Q9BZP6 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9718468 0.81 ESR1 (0.60) RELAMAPTKMT2ARAB9ANPC1
SCHEMBL14564630 0.81 MAPT (0.56) MAPTKMT2ARAB9ASMN1; SMN2ALDH1A1
SCHEMBL12449789 0.80 AKR1C1 (0.50) MAPTKMT2AALDH1A1MAPK1L3MBTL1
SCHEMBL911941 0.80 AKR1C1 (0.50) MAPTKMT2AALDH1A1MAPK1L3MBTL1
SCHEMBL1567874 0.80 AKR1C1 (0.50) MAPTKMT2AALDH1A1MAPK1L3MBTL1
SCHEMBL8803174 0.77 CYP19A1 (0.50) RAB9ANPC1SMN1; SMN2CYP1B1ALDH1A1
SCHEMBL391071 0.76 MAPT (0.54) RELAMAPTKMT2ARAB9ANPC1
SCHEMBL391070 0.76 MAPT (0.58) RELAMAPTKMT2ARAB9ANPC1
SCHEMBL8923931 0.76 CYP1B1 (0.49) MAPTRAB9ANPC1SMN1; SMN2CYP1B1
SCHEMBL10439735 0.76 CYP1B1 (0.49) MAPTKMT2ARAB9ANPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2379493-A1 PROCESS FOR THE PREPARATION OF ASYMMETRICAL BIS(THIOSEMICARBAZONES) The University of Melbourne (AU) 2011-10-26 EP disclosed
WO-2010066010-A1 PROCESS FOR THE PREPARATION OF ASYMMETRICAL BIS(THIOSEMICARBAZONES) THE UNIVERSITY OF MELBOURNE (AU) 2010-06-17 WO disclosed