Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | GPR3 | P46089 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CCR1 | P32246 | 3/20 | 0.38 |
| ▸ | CCR8 | P51685 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | F12 | P00748 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488607 | 0.83 | KDM4E (0.58) | CYP2A6CYP1A2GPR3KDM4ECCR1 | |
| SCHEMBL24183817 | 0.79 | CYP2A6 (0.42) | CYP2A6CYP1A2GPR3KDM4ECCR1 | |
| SCHEMBL19748987 | 0.79 | KDM4E (0.60) | CYP2A6CYP1A2GPR3KDM4ECCR1 | |
| SCHEMBL2490181 | 0.77 | KDM4E (0.44) | CYP2A6CYP1A2GPR3KDM4ECCR1 | |
| SCHEMBL19007837 | 0.76 | CCR1 (0.51) | CYP2A6CYP1A2GPR3KDM4ECCR1 | |
| SCHEMBL24183837 | 0.76 | CYP2A6 (0.55) | CYP2A6CYP1A2GPR3KDM4ECCR1 | |
| SCHEMBL19007827 | 0.74 | CYP2A6 (0.50) | CYP2A6CYP1A2GPR3KDM4ENPC1 | |
| SCHEMBL18252753 | 0.74 | GPR3 (0.52) | CYP2A6CYP1A2GPR3KDM4EL3MBTL1 | |
| SCHEMBL10063498 | 0.74 | CYP2A6 (0.43) | CYP2A6CYP1A2GPR3KDM4ECCR1 | |
| SCHEMBL30779331 | 0.74 | CYP2A6 (0.43) | CYP2A6CYP1A2GPR3KDM4ECCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991546-B1 | NOVEL DIBENZO[c,h][1,5]NAPHTHYRIDINES AND THEIR USE AS DNA PROBES | INST CURIE (FR) | 2011-10-26 | — | — | EP | disclosed |
| US-7728128-B2 | Dibenzo[c,h][1,5]naphthyridines and their use as DNA probes | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICATE (INSERM) (FR) | 2010-06-01 | — | — | US | disclosed |
| US-7728128-B2 | Dibenzo[c,h][1,5]naphthyridines and their use as DNA probes | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICATE (INSERM) (FR) | 2010-06-01 | — | — | US | disclosed |
| US-7728128-B2 | Dibenzo[c,h][1,5]naphthyridines and their use as DNA probes | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICATE (INSERM) (FR) | 2010-06-01 | — | — | US | disclosed |
| US-20090246772-A1 | NOVEL DIBENZO[c,h][1,5]NAPHTHYRIDINES AND THEIR USE AS DNA PROBES | INSTITUT CURIE (FR) | 2009-10-01 | — | — | US | disclosed |
| US-20090246772-A1 | NOVEL DIBENZO[c,h][1,5]NAPHTHYRIDINES AND THEIR USE AS DNA PROBES | INSTITUT CURIE (FR) | 2009-10-01 | — | — | US | disclosed |
| US-20090246772-A1 | NOVEL DIBENZO[c,h][1,5]NAPHTHYRIDINES AND THEIR USE AS DNA PROBES | INSTITUT CURIE (FR) | 2009-10-01 | — | — | US | disclosed |
| EP-1991546-A1 | NOVEL DIBENZO[c,h][1,5]NAPHTHYRIDINES AND THEIR USE AS DNA PROBES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007096728-A1 | NOVEL DIBENZO[c,h][1,5]NAPHTHYRIDINES AND THEIR USE AS DNA PROBES | INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) (FR) | 2007-08-30 | — | — | WO | disclosed |
| EP-1826210-A1 | Novel dibenzo[c,h][1,5]naphthyridines and their use as DNA probes | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2007-08-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090246772-A1 | NOVEL DIBENZO[c,h][1,5]NAPHTHYRIDINES AND THEIR USE AS DNA PROBES | DNA2, DDB1, H1-5 | CYP2A6 655/4885CYP1A2 398/4885GPR3 3651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.