Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTSR1 | P30989 | 5/20 | 0.40 |
| ▸ | NTSR2 | O95665 | 2/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.36 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | PAICS | P22234 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | CTSA | P10619 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL544195 | 0.99 | NTSR1 (0.41) | NTSR1NTSR2SLC6A9FPR3GPR183 | |
| SCHEMBL16493619 | 0.94 | NTSR1 (0.41) | NTSR1NTSR2FPR3GPR183SORT1 | |
| Hydrochloric Acid SCHEMBL544132 | 0.94 | NTSR1 (0.40) | NTSR1NTSR2SLC6A9FPR3GPR183 | |
| SCHEMBL913663 | 0.94 | NTSR1 (0.36) | NTSR1NTSR2SLC6A9CNR2PAICS | |
| Hydrochloric Acid SCHEMBL544553 | 0.93 | NTSR1 (0.42) | NTSR1NTSR2FPR3GPR183SORT1 | |
| Hydrochloric Acid SCHEMBL544987 | 0.93 | NTSR1 (0.40) | NTSR1NTSR2FPR3GPR183SORT1 | |
| Hydrochloric Acid SCHEMBL544901 | 0.93 | NTSR1 (0.45) | NTSR1NTSR2FPR3GPR183SORT1 | |
| Hydrochloric Acid SCHEMBL544420 | 0.93 | NTSR1 (0.40) | NTSR1NTSR2FPR3GPR183SORT1 | |
| Hydrochloric Acid SCHEMBL544785 | 0.91 | NTSR1 (0.39) | NTSR1NTSR2FPR3GPR183SORT1 | |
| Hydrochloric Acid SCHEMBL543957 | 0.90 | NTSR1 (0.40) | NTSR1NTSR2FPR3GPR183SORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238110-B1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI SA (FR) | 2011-10-26 | — | — | EP | claimed |
| EP-2238110-A1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | Sanofi-Aventis (FR) | 2010-10-13 | — | — | EP | claimed |
| WO-2009115665-A1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI-AVENTIS (FR) | 2009-09-24 | — | — | WO | claimed |
| EP-2238110-B1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI SA (FR) | 2011-10-26 | — | — | EP | disclosed |
| EP-2238110-A1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | Sanofi-Aventis (FR) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009115665-A1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI-AVENTIS (FR) | 2009-09-24 | — | — | WO | disclosed |