Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | HPGD | P15428 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24890775 | 0.98 | NPC1 (0.57) | NPC1ALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL24891020 | 0.86 | NPC1 (0.57) | NPC1ALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL21946675 | 0.84 | GNAI3 (0.40) | NPC1ALDH1A1RAB9AGNAI3GNAO1 | |
| SCHEMBL27456239 | 0.84 | NPC1 (0.59) | NPC1ALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL21946396 | 0.84 | NPC1 (0.39) | NPC1ALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL14274126 | 0.84 | NPC1 (0.59) | NPC1ALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL14294014 | 0.84 | NPC1 (0.59) | NPC1ALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL12410266 | 0.83 | NPC1 (0.62) | NPC1ALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL23484938 | 0.83 | NPC1 (0.39) | NPC1ALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL15224251 | 0.83 | NPC1 (0.71) | NPC1ALDH1A1HPGDKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023004163-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK WITH ENHANCED IMID ACTIVITY | NURIX THERAPEUTICS, INC. (US) | 2023-01-26 | — | — | WO | disclosed |
| WO-2023287928-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK WITH DIMINISHED IMID ACTIVITY | NURIX THERAPEUTICS, INC. (US) | 2023-01-19 | — | — | WO | disclosed |