Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.43 |
| ▸ | CA1 | P00915 | 13/20 | 0.39 |
| ▸ | CA12 | O43570 | 5/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 9/20 | 0.35 |
| ▸ | CA7 | P43166 | 3/20 | 0.34 |
| ▸ | CA3 | P07451 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 2/20 | 0.34 |
| ▸ | CA6 | P23280 | 2/20 | 0.34 |
| ▸ | CA5A | P35218 | 2/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2274095 | 0.78 | NPSR1 (0.39) | CA2CA1CA12CA14CA9 | |
| SCHEMBL13359386 | 0.77 | CA12 (0.40) | CA1CA12CA9 | |
| Sulfuric Acid SCHEMBL5874269 | 0.75 | CA1 (0.46) | CA2CA1CA12CA9 | |
| Sulfuric Acid SCHEMBL2148402 | 0.75 | CA1 (0.46) | CA2CA1CA12CA9 | |
| Sulfuric Acid SCHEMBL27883459 | 0.75 | CA1 (0.46) | CA2CA1CA12CA9 | |
| SCHEMBL2826 | 0.75 | — | — | |
| SCHEMBL588172 | 0.75 | — | — | |
| SCHEMBL3903880 | 0.74 | NPSR1 (0.46) | CA2CA1CA12CA14CA9 | |
| Hydrazine SCHEMBL28329366 | 0.74 | MAPT (0.44) | CA1CA12CA9MAPT | |
| SCHEMBL3904839 | 0.74 | TSHR (0.46) | CA1CA12CA9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379496-A1 | SULFONAMIDES AS TRPM8 MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010080398-A1 | SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-15 | — | — | WO | disclosed |