Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 4/20 | 0.38 |
| ▸ | ILK | Q13418 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15074585 | 0.75 | HSP90AA1 (0.43) | GRM4HSP90AA1NPC1L3MBTL1PRMT5 | |
| SCHEMBL19100788 | 0.74 | POLB (0.43) | GRM4NPC1EGFRTLR8TLR7 | |
| SCHEMBL2330553 | 0.71 | MAPT (0.48) | GRM4HSP90AA1NPC1L3MBTL1PRMT5 | |
| SCHEMBL19853487 | 0.71 | CYP1A2 (0.50) | ILKKDM4EMTORPBRM1ALDH1A1 | |
| SCHEMBL15070856 | 0.70 | CCNB2 (0.39) | GRM4HSP90AA1NPC1L3MBTL1PRMT5 | |
| SCHEMBL21672127 | 0.70 | GRM4 (0.38) | GRM4HSP90AA1NPC1L3MBTL1PRMT5 | |
| SCHEMBL29705608 | 0.67 | GRM4 (0.50) | GRM4 | |
| SCHEMBL15435736 | 0.67 | GRM4 (0.50) | GRM4 | |
| SCHEMBL18208663 | 0.66 | KDM4E (0.40) | GRM4L3MBTL1KDM4ELMNACYP3A4 | |
| SCHEMBL1311427 | 0.66 | PARP1 (0.39) | HSP90AA1KDM4EGMNNLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023287793-A1 | THERAPEUTIC COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2023-01-19 | — | — | WO | disclosed |