Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 3/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367804 | 0.87 | CHKA (0.82) | CHKAHDAC6HRH3HDAC1HDAC4 | |
| SCHEMBL64588 | 0.87 | CHKA (0.82) | CHKAHDAC6HRH3HDAC1HDAC4 | |
| SCHEMBL25509878 | 0.82 | CHKA (0.64) | CHKAHDAC6HRH3HDAC1HDAC4 | |
| SCHEMBL347958 | 0.81 | CHKA (0.62) | CHKAHDAC6HRH3LMNAKDM4E | |
| SCHEMBL10154345 | 0.81 | HDAC6 (0.78) | CHKAHDAC6HRH3HDAC1HDAC4 | |
| SCHEMBL7058977 | 0.80 | HDAC6 (0.68) | CHKAHDAC6HRH3HDAC1HDAC4 | |
| SCHEMBL6650843 | 0.80 | CHKA (0.61) | CHKAHDAC6HRH3HDAC1HDAC4 | |
| SCHEMBL25142596 | 0.80 | CHKA (0.61) | CHKAHDAC6HRH3HDAC1HDAC4 | |
| SCHEMBL28061494 | 0.80 | HDAC6 (0.71) | CHKAHDAC6HRH3HDAC1HDAC4 | |
| SCHEMBL1979654 | 0.79 | CHKA (0.60) | CHKAHDAC6HRH3BTKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023287793-A1 | THERAPEUTIC COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2023-01-19 | — | — | WO | disclosed |