Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.51 |
| ▸ | TNKS | O95271 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | TOP1 | P11387 | 3/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488339 | 0.93 | CHRM1 (0.53) | CHRM1HTR1ADRD4HTR2ASLC6A4 | |
| SCHEMBL2488155 | 0.93 | CHRM1 (0.53) | CHRM1HTR1ADRD4HTR2ASLC6A4 | |
| SCHEMBL2488335 | 0.90 | CHRM1 (0.51) | CHRM1TDO2 | |
| SCHEMBL2488856 | 0.89 | CHRM1 (0.66) | CHRM1TNKSDRD3TOP1 | |
| SCHEMBL2490145 | 0.84 | CHRM1 (0.59) | CHRM1TOP1 | |
| SCHEMBL2487941 | 0.84 | CHRM1 (0.58) | CHRM1TOP1 | |
| SCHEMBL2488388 | 0.83 | CHRM1 (0.56) | CHRM1TOP1 | |
| SCHEMBL2492079 | 0.83 | CHRM1 (0.57) | CHRM1TOP1 | |
| SCHEMBL2488124 | 0.82 | CHRM1 (0.55) | CHRM1TOP1 | |
| SCHEMBL2485899 | 0.81 | CHRM1 (0.69) | CHRM1TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |