Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.58 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.35 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490145 | 0.91 | CHRM1 (0.59) | CHRM1SLC5A1SLC5A2MAPTTP53 | |
| SCHEMBL2488388 | 0.88 | CHRM1 (0.56) | CHRM1SLC5A1SLC5A2TOP1SMN1; SMN2 | |
| SCHEMBL2489039 | 0.88 | CHRM1 (0.74) | CHRM1MAPTTP53TOP1 | |
| SCHEMBL2485615 | 0.87 | CHRM1 (0.77) | CHRM1TOP1 | |
| SCHEMBL2488124 | 0.87 | CHRM1 (0.55) | CHRM1SLC5A1SLC5A2MAPTTOP1 | |
| SCHEMBL2485661 | 0.87 | CHRM1 (0.61) | CHRM1TOP1 | |
| SCHEMBL2488155 | 0.86 | CHRM1 (0.53) | CHRM1TOP1 | |
| SCHEMBL2488339 | 0.86 | CHRM1 (0.53) | CHRM1SLC5A1SLC5A2TOP1 | |
| SCHEMBL2491670 | 0.85 | CHRM1 (0.52) | CHRM1TOP1 | |
| SCHEMBL2492079 | 0.84 | CHRM1 (0.57) | CHRM1SLC5A1SLC5A2MAPTTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |