Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23866608 | 0.84 | PKM (0.42) | PKMGAACFTRCETPKMT2A | |
| SCHEMBL12975771 | 0.79 | TSHR (0.39) | GAATSHRUSP2HSD17B10CA1 | |
| SCHEMBL12975401 | 0.79 | TSHR (0.39) | GAATSHRUSP2HSD17B10CA1 | |
| SCHEMBL12975777 | 0.79 | TSHR (0.39) | GAATSHRUSP2HSD17B10CA1 | |
| SCHEMBL14465241 | 0.78 | GAA (0.37) | GAATSHRUSP2HSD17B10CA1 | |
| SCHEMBL9462919 | 0.77 | CYP2D6 (0.52) | GAATSHRUSP2HSD17B10KMT2A | |
| SCHEMBL24333753 | 0.76 | PKM (0.42) | PKMGAACFTRCETPMEN1 | |
| SCHEMBL12268658 | 0.76 | GAA (0.40) | GAATSHRUSP2HSD17B10CA1 | |
| SCHEMBL21661029 | 0.76 | PKM (0.42) | PKMGAACFTRCETPMEN1 | |
| SCHEMBL24762817 | 0.75 | GAA (0.38) | GAATSHRUSP2HSD17B10CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023288242-A1 | PI3Kα INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2023-01-19 | — | — | WO | disclosed |