Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 4/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30190089 | 1.00 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22798652 | 0.85 | BCHE (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22527528 | 0.83 | AR (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22527530 | 0.83 | AR (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22527529 | 0.83 | AR (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21806792 | 0.81 | KCNA5 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21806790 | 0.81 | KCNA5 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21806791 | 0.81 | KCNA5 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9895268 | 0.80 | CTSL (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10002313 | 0.80 | CTSL (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023288254-A1 | HETEROCYCLIC COMPOUNDS AS MAP4K1 INHIBITORS | BLUEPRINT MEDICINES CORPORATION (US) | 2023-01-19 | — | — | WO | disclosed |