Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 20/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12207407 | 1.00 | GSK3B (0.51) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL3744700 | 0.88 | GSK3B (0.54) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL3746568 | 0.88 | GSK3B (0.54) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL2487950 | 0.84 | GSK3B (0.51) | GSK3BCYP2D6 | |
| SCHEMBL14300347 | 0.84 | GSK3B (0.51) | GSK3BCYP2D6 | |
| SCHEMBL2491310 | 0.84 | GSK3B (0.59) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL13046796 | 0.76 | GSK3B (0.54) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL2488521 | 0.76 | GSK3B (0.61) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL14300349 | 0.76 | GSK3B (0.61) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL2488560 | 0.76 | GSK3B (0.53) | GSK3BCYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057141-B1 | PYRIMIDONE COMPOUNDS AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2008023239-A1 | PYRIMIDONE COMPOUNDS AS GSK-3 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-28 | — | — | WO | disclosed |