Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19016231 | 0.92 | MAP4K4 (0.46) | HRH3MAP4K4KCNH2KDM4ESMN1; SMN2 | |
| SCHEMBL14507938 | 0.83 | HRH3 (0.49) | HRH3MAP4K4KCNH2KDM4ESMN1; SMN2 | |
| SCHEMBL19008170 | 0.83 | MAP4K4 (0.44) | MAP4K4KCNH2CXCR4CYP2D6GHSR | |
| SCHEMBL12090380 | 0.83 | KCNH2 (0.53) | HRH3MAP4K4KCNH2KDM4ESMN1; SMN2 | |
| SCHEMBL3985142 | 0.80 | HRH3 (0.46) | HRH3MAP4K4KCNH2KDM4ESMN1; SMN2 | |
| SCHEMBL2603281 | 0.79 | CARM1 (0.55) | HRH3KCNH2CYP2D6CYP3A4LMNA | |
| SCHEMBL12090211 | 0.77 | MAP4K4 (0.49) | HRH3MAP4K4KCNH2KDM4ESMN1; SMN2 | |
| SCHEMBL21078309 | 0.76 | KDM4E (0.49) | HRH3MAP4K4KCNH2KDM4ESMN1; SMN2 | |
| SCHEMBL1515203 | 0.76 | HPGD (0.49) | HRH3KDM4ESMN1; SMN2 | |
| SCHEMBL13995043 | 0.75 | HRH3 (0.50) | HRH3KCNH2KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011117254-A1 | PIPERIDINE AMIDES AS MODULATORS OF THE GHRELIN RECEPTOR | PROSIDION LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |