Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12090380 | 0.84 | KCNH2 (0.53) | HRH3KDM4ESMN1; SMN2MAP4K4KCNH2 | |
| SCHEMBL2490313 | 0.80 | HRH3 (0.45) | HRH3KDM4ESMN1; SMN2MAP4K4KCNH2 | |
| SCHEMBL12090211 | 0.78 | MAP4K4 (0.49) | HRH3KDM4ESMN1; SMN2MAP4K4KCNH2 | |
| SCHEMBL9912161 | 0.78 | PRMT6 (0.68) | CARM1PRMT6KCNH2 | |
| SCHEMBL1515203 | 0.77 | HPGD (0.49) | HRH3KDM4ESMN1; SMN2HTR6 | |
| SCHEMBL21370032 | 0.76 | OGA (0.50) | KDM4ESMN1; SMN2CARM1PRMT6PDE2A | |
| SCHEMBL803676 | 0.76 | LMNA (0.50) | KDM4ESMN1; SMN2KCNH2PDE2AALDH1A1 | |
| SCHEMBL3979979 | 0.75 | CARM1 (0.50) | HRH3CARM1PRMT6MAP4K4LMNA | |
| SCHEMBL8911524 | 0.75 | HPGD (0.55) | HRH3KDM4ESMN1; SMN2ALDH1A1HTR6 | |
| SCHEMBL30191193 | 0.75 | KCNH2 (0.47) | HRH3KDM4ESMN1; SMN2MAP4K4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118092-A1 | NEW N, N'- 2,4-DIANILINOPYRIMIDINE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS ESSENTIALLY AS IKK INHIBITORS | Sanofi-Aventis (FR) | 2009-11-18 | — | — | EP | disclosed |
| WO-2009056693-A1 | NOVEL DERIVATIVES OF N, N'- 2, 4-DIANILINOPYRIMIDINES, PREPARATION THEREOF AS MEDICAMENTS PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS IKK INHIBITORS | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | WO | disclosed |
| WO-2008099073-A1 | N, N' -2, 4-DIANILINOPYRIMIDINES PREPARATION AND USE THEREOF AS IKK INHIBITORS PREPARATION AND TEH PHARMACUETICAL COMPOSITIONS THEREOF | SANOFI-AVENTIS (FR) | 2008-08-21 | — | — | WO | disclosed |