Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | PIM1 | P11309 | 1/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 4/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.45 |
| ▸ | HNF4A | P41235 | 1/20 | 0.45 |
| ▸ | MAP2 | P11137 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28308851 | 0.82 | KDM4E (0.47) | KDM4EMAPTPIM1GFERTDP1 | |
| SCHEMBL7042649 | 0.78 | ESR1 (0.56) | KDM4EMAPTPIM1GFERTDP1 | |
| SCHEMBL6691511 | 0.77 | KDM4E (1.00) | KDM4EMAPTPIM1GFERTDP1 | |
| SCHEMBL15484969 | 0.77 | PARP1 (0.60) | KDM4EMAPTPIM1GFERTDP1 | |
| SCHEMBL4413365 | 0.77 | KDM4E (0.52) | KDM4EMAPTPIM1GFERTDP1 | |
| SCHEMBL6624663 | 0.77 | GPR17 (0.53) | KDM4EMAPTPIM1GFERTDP1 | |
| SCHEMBL28983296 | 0.76 | ESR1 (0.58) | KDM4EMAPTPIM1GFERTDP1 | |
| SCHEMBL28288597 | 0.76 | KDM4E (0.53) | KDM4EMAPTPIM1GFERTDP1 | |
| SCHEMBL2183473 | 0.76 | PARP1 (0.73) | KDM4EMAPTPIM1GFERTDP1 | |
| SCHEMBL30455376 | 0.76 | PARP1 (0.73) | KDM4EMAPTPIM1GFERTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130203726-A1 | FtsZ INHIBITORS AS POTENTIATORS OF BETA-LACTAM ANTIBIOTICS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS | ROEMER TERRY (US) | 2013-08-08 | — | — | US | disclosed |
| EP-2544528-A1 | FtsZ INHIBITORS AS POTENTIATORS OF BETA-LACTAM ANTIBIOTICS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS | Merck Sharp & Dohme Corp. (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112435-A1 | FtsZ INHIBITORS AS POTENTIATORS OF BETA-LACTAM ANTIBIOTICS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS | MERCK SHARP & DOHME CORP. (US) | 2011-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203726-A1 | FtsZ INHIBITORS AS POTENTIATORS OF BETA-LACTAM ANTIBIOTICS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS | RCE1, POLE3, MCRS1 | KDM4E 1307/4885MAPT 471/4885PIM1 2492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.