Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | FABP6 | P51161 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 7/20 | 0.34 |
| ▸ | VRK1 | Q99986 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2526044 | 0.86 | MAPT (0.46) | AURKAAURKBRAF1BRAF | |
| SCHEMBL13341372 | 0.82 | PARG (0.35) | AURKAAURKBPARGVRK1ROCK2 | |
| SCHEMBL13341615 | 0.80 | NPC1 (0.41) | CSNK1E | |
| SCHEMBL2491924 | 0.79 | AURKA (0.45) | AURKAAURKBFABP6CHEK1SRC | |
| SCHEMBL13367949 | 0.79 | AURKA (0.47) | AURKAAURKBFABP6CHEK1SRC | |
| SCHEMBL2488865 | 0.78 | AURKA (0.42) | AURKAAURKBFABP6PARGCHEK1 | |
| SCHEMBL2490810 | 0.76 | AURKA (0.40) | AURKAAURKBFABP6RAF1BRAF | |
| SCHEMBL12207656 | 0.76 | AURKA (0.40) | AURKAAURKBFABP6RAF1BRAF | |
| SCHEMBL2487407 | 0.76 | AURKA (0.64) | AURKAAURKBFABP6CHEK1SRC | |
| SCHEMBL3424973 | 0.75 | AURKA (0.44) | AURKAAURKBFABP6CHEK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756112-B1 | PYRROLOBENZIMIDAZOLONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS | BOEHRINGER INGELHEIM INT (DE) | 2011-10-26 | — | — | EP | disclosed |
| US-7714010-B2 | Pyrrolobenzimidazolones and their use as anti-proliferative agents | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-05-11 | — | — | US | disclosed |
| US-7714010-B2 | Pyrrolobenzimidazolones and their use as anti-proliferative agents | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-05-11 | — | — | US | disclosed |