Citric Acid

Citric Acid

SCHEMBL2490516

CCOC(N)=O.O=C(O)CC(O)(CC(=O)O)C(=O)O

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.38
ALDH1A1 P00352 3/20 0.58
ALOX15 P16050 2/20 0.58
SLC13A5 Q86YT5 9/20 0.40
KDM4E B2RXH2 3/20 0.40
LMNA P02545 3/20 0.40
TSHR P16473 2/20 0.40
MAPT P10636 2/20 0.40
CYP2D6 P10635 2/20 0.38
CYP1A2 P05177 1/20 0.38
KMT2A Q03164 1/20 0.38
HMGCR P04035 1/20 0.37
CHRM1 P11229 1/20 0.37
TBXA2R P21731 1/20 0.37
ADRA1A P35348 1/20 0.37
EGLN1 Q9GZT9 1/20 0.36
HSD17B10 Q99714 1/20 0.36
CYP2C19 P33261 1/20 0.35
HIF1A Q16665 1/20 0.35
SLC13A2 Q13183 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL72953 0.82 ALDH1A1 (0.60) ALDH1A1ALOX15SLC13A5KDM4ELMNA
Citric Acid SCHEMBL4292973 0.82 ALDH1A1 (0.60) ALDH1A1ALOX15SLC13A5KDM4ELMNA
Citric Acid SCHEMBL2238478 0.82 ALDH1A1 (0.60) ALDH1A1ALOX15SLC13A5KDM4ELMNA
SCHEMBL30384961 0.82 ALDH1A1 (0.60) ALDH1A1ALOX15SLC13A5KDM4ELMNA
Citric Acid SCHEMBL11169125 0.81 ALDH1A1 (0.54) ALDH1A1ALOX15SLC13A5KDM4ELMNA
SCHEMBL16737228 0.81 ALDH1A1 (0.58) ALDH1A1ALOX15SLC13A5KDM4ELMNA
Water SCHEMBL28164707 0.81 ALDH1A1 (0.58) ALDH1A1ALOX15SLC13A5KDM4ELMNA
SCHEMBL433131 0.81 ALDH1A1 (0.58) ALDH1A1ALOX15SLC13A5KDM4ELMNA
SCHEMBL27981114 0.81 ALDH1A1 (0.58) ALDH1A1ALOX15SLC13A5KDM4ELMNA
Ammonia Solution, Strong SCHEMBL29179739 0.81 ALDH1A1 (0.58) ALDH1A1ALOX15SLC13A5KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1540071-B1 FLUORINATED TREATMENT FOR SOIL RESISTANCE DU PONT (US) 2011-11-09 EP claimed
EP-1540072-B1 CARPETS TREATED FOR SOIL RESISTANCE DU PONT (US) 2011-10-26 EP claimed
US-20080196168-A1 Washable leather with repellency E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-08-21 US claimed
EP-1859065-A1 WASHABLE LEATHER WITH OIL- AND WATER-REPELLENCY E.I. DUPONT DE NEMOURS AND COMPANY (US) 2007-11-28 EP claimed
WO-2006091690-A1 WASHABLE LEATHER WITH OIL- AND WATER-REPELLENCY E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-08-31 WO claimed
US-20060188729-A1 Washable leather with repellency E. I. DU PONT DE NEMOURS AND COMPANY 2006-08-24 US claimed
CN-1671914-A Carpets treated for soil resistance DU PONT (US) 2005-09-21 CN claimed
EP-1540071-A2 FLUORINATED TREATMENT FOR SOIL RESISTANCE E.I. DU PONT DE NEMOURS AND COMPANY (US) 2005-06-15 EP claimed
EP-1540072-A2 CARPETS TREATED FOR SOIL RESISTANCE E.I. DU PONT DE NEMOURS AND COMPANY (US) 2005-06-15 EP claimed
US-6824854-B2 INCREASING THE HALOGEN-FREE ANIONIC SURFACTANT CONCENTRATION TO IMPROVE ITS PERFORMANCE, AND STABLE DISPERSION E. I. DU PONT DE NEMOURS AND COMPANY 2004-11-30 US claimed
JP-2001501105-A 2001-01-30 JP claimed
EP-0927274-A1 RUG AND CARPET UNDERLAYS SUBSTANTIALLY IMPERVIOUS TO LIQUIDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1999-07-07 EP claimed
US-5763040-A Rug and carpet underlays substantially impervious to liquids E. I. DU PONT DE NEMOURS AND COMPANY (US) 1998-06-09 US claimed
WO-1998012375-A1 RUG AND CARPET UNDERLAYS SUBSTANTIALLY IMPERVIOUS TO LIQUIDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-03-26 WO claimed
EP-0821747-A1 RUG UNDERLAY SUBSTANTIALLY IMPERVIOUS TO LIQUIDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-02-04 EP claimed
US-5601910-A CONTAINING REPELLENT FINISH OF FLUOROCHEMICALS, SILICONES, WAX EMULSIONS, OILS, ALKYL(METH)ACRYLATE RESINS OR MIXTURES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1997-02-11 US claimed
WO-1996033307-A1 RUG UNDERLAY SUBSTANTIALLY IMPERVIOUS TO LIQUIDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1996-10-24 WO claimed
US-4388372-A POLYAMIDE YARN, EPOXY RESIN-CARBOXY POLYMER-TERT-AMINE PRODUCT, PERFLUOROALKYL CITRATE URETHANE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1983-06-14 US claimed
US-4325857-A PERFLUOROALKYL CITRATE URETHANE, CARBOXYLIC ACID ADDITION POLYMER-EPOXY RESIN-TERT-AMINE PRODUCT E. I. DU PONT DE NEMOURS AND COMPANY (US) 1982-04-20 US claimed
US-4029585-A SOIL AND FLAME RESISTANCE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-06-14 US claimed