Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 10/20 | 0.56 |
| ▸ | HPGD | P15428 | 10/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462605 | 0.92 | TSHR (0.56) | TSHRHPGDKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL2456621 | 0.88 | ALDH1A1 (0.65) | TSHRHPGDKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL2464296 | 0.87 | ALDH1A1 (0.60) | TSHRHPGDKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL2456749 | 0.87 | HPGD (0.60) | TSHRHPGDKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL2462442 | 0.86 | HPGD (0.61) | TSHRHPGDKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL2456863 | 0.84 | TSHR (0.59) | TSHRHPGDKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL2462147 | 0.84 | HPGD (0.59) | TSHRHPGDKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL2459949 | 0.84 | HPGD (0.77) | TSHRHPGDKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL2459035 | 0.84 | TSHR (0.61) | TSHRHPGDKDM4EHSD17B10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2456616 | 0.83 | TSHR (0.60) | TSHRHPGDKDM4EHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948663-B1 | PYRAZOLO-PYRIMIDINES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS INC (US) | 2011-09-14 | — | — | EP | claimed |