Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 4/20 | 0.48 |
| ▸ | CDK2 | P24941 | 4/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8237569 | 0.81 | CCNA2 (0.51) | CCNA2CDK2CDK5CDK5R1CCNT1 | |
| SCHEMBL14947686 | 0.81 | CCNA2 (0.51) | CCNA2CDK2CDK5CDK5R1CCNT1 | |
| SCHEMBL8233834 | 0.79 | CCNA2 (0.50) | CCNA2CDK2CDK5CDK5R1CCNT1 | |
| SCHEMBL13039420 | 0.76 | CDC7 (0.47) | CCNA2CDK2CCNT1CDK9CCNA1 | |
| SCHEMBL2460112 | 0.75 | DYRK1B (0.34) | CCNA2CDK2CDK5CDK5R1CCNT1 | |
| SCHEMBL5205411 | 0.73 | CCNT1 (0.44) | CCNA2CDK2CDK5CDK5R1CCNT1 | |
| SCHEMBL1554639 | 0.73 | MAPK14 (0.54) | CCNA2CDK2CDK5CDK5R1CCNT1 | |
| SCHEMBL13039430 | 0.72 | DHODH (0.46) | CCNA2CDK2CCNA1MAPK14MAPK13 | |
| SCHEMBL13199646 | 0.71 | CCNT1 (0.46) | CCNA2CDK2CDK5CDK5R1CCNT1 | |
| SCHEMBL3255992 | 0.70 | LMNA (0.47) | CCNA2CDK2CDK5CDK5R1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021143729-A1 | COMPOUND, COMPOSITION AND FUNCTIONAL MOLECULE WITH MULTI-TARGET INHIBITING EFFECT AND USE THEREOF | 中国科学院上海药物研究所 | 2021-07-22 | — | — | WO | disclosed |
| US-8367687-B2 | Pyrazole derivatives | NOVARTIS AG (CH) | 2013-02-05 | — | — | US | disclosed |
| EP-2231636-B1 | PYRAZOLE DERIVATIVES AND USE THEREOF AS INHIBITORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2011-09-14 | — | — | EP | disclosed |
| US-20100280033-A1 | Pyrazole Derivatives | NOVARTIS AG | 2010-11-04 | — | — | US | disclosed |
| EP-2231636-A1 | PYRAZOLE DERIVATIVES AND USE THEREOF AS INHIBITORS OF CYCLIN DEPENDENT KINASES | Novartis AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009071701-A1 | PYRAZOLE DERIVATIVES AND USE THEREOF AS INHIBITORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280033-A1 | Pyrazole Derivatives | PRKDC, PRKACA, PDK2 | CCNA2 627/4885CDK2 16/4885CDK5 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.