Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23478141 | 0.74 | GRM5 (0.36) | GRM5CSNK2A1PGR | |
| SCHEMBL23478145 | 0.71 | METAP2 (0.38) | GRM5CSNK2A1 | |
| SCHEMBL29780227 | 0.71 | METAP2 (0.38) | GRM5CSNK2A1 | |
| SCHEMBL1984025 | 0.65 | GRM5 (0.44) | GRM5CSNK2A1PGR | |
| SCHEMBL27371490 | 0.65 | CDC7 (0.33) | — | |
| SCHEMBL27371484 | 0.65 | MEN1 (0.37) | — | |
| SCHEMBL30751325 | 0.63 | GRM5 (0.43) | GRM5PGR | |
| SCHEMBL27374617 | 0.63 | GRM5 (0.43) | GRM5PGR | |
| SCHEMBL23478136 | 0.63 | GRM5 (0.36) | GRM5CSNK2A1 | |
| SCHEMBL30751479 | 0.63 | IDH1 (0.42) | GRM5CSNK2A1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230024438-A1 | INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230024438-A1 | INHIBITORS OF HIF-2ALPHA | HIF1AN, HIF1A, EGLN2 | GRM5 3984/4885CSNK2A1 909/4885TP53 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.