Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.43 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | TYR | P14679 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12733032 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP2C9TP53CYP2C19HIF1A | |
| SCHEMBL31497679 | 0.87 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP2C9TP53CYP2C19HIF1A | |
| SCHEMBL19997077 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP2C9TP53CYP2C19HIF1A | |
| SCHEMBL12162725 | 0.83 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP2C9TP53CYP2C19HIF1A | |
| SCHEMBL15701548 | 0.81 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP2C9TP53CYP2C19HIF1A | |
| SCHEMBL16117670 | 0.81 | ALDH1A1 (0.67) | SMN1; SMN2CYP2C9TP53CYP2C19HIF1A | |
| SCHEMBL19163700 | 0.81 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP2C9TP53CYP2C19HIF1A | |
| SCHEMBL12933506 | 0.81 | GAA (0.46) | SMN1; SMN2CYP2C9TP53CYP2C19HIF1A | |
| SCHEMBL7132801 | 0.78 | ALDH1A1 (0.53) | SMN1; SMN2CYP2C9TP53CYP2C19HIF1A | |
| SCHEMBL13911912 | 0.78 | ALDH1A1 (0.41) | SMN1; SMN2CYP2C9TP53CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230019280-A1 | SUBSTITUTED ISOINDOLONYL 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2023-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230019280-A1 | SUBSTITUTED ISOINDOLONYL 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | HAVCR2, CDV3, HCCS | SMN1; SMN2 4152/4885CYP2C9 491/4885TP53 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.