Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 7/20 | 0.45 |
| ▸ | TTK | P33981 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25443942 | 0.91 | PTK6 (0.55) | PTK6LCKAURKB | |
| SCHEMBL30171841 | 0.91 | PTK6 (0.44) | PTK6TTKSMN1; SMN2LCKALDH1A1 | |
| SCHEMBL22139061 | 0.91 | PTK6 (0.44) | PTK6TTKSMN1; SMN2LCKALDH1A1 | |
| SCHEMBL25445003 | 0.88 | PTK6 (0.44) | PTK6TTKLCKALDH1A1AURKB | |
| SCHEMBL22139097 | 0.85 | PTK6 (0.48) | PTK6TTKLCKAURKB | |
| SCHEMBL22123995 | 0.83 | PTK6 (0.48) | PTK6TTKLCKAURKB | |
| SCHEMBL22139059 | 0.82 | PTK6 (0.44) | PTK6TTKSMN1; SMN2LCKALDH1A1 | |
| SCHEMBL30171781 | 0.82 | PTK6 (0.49) | PTK6TTKLCKAURKB | |
| SCHEMBL22124042 | 0.82 | PTK6 (0.49) | PTK6TTKLCKAURKB | |
| SCHEMBL30171977 | 0.82 | PTK6 (0.44) | PTK6TTKSMN1; SMN2LCKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898630-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-05-10 | — | — | EP | disclosed |
| EP-3898629-B1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |
| EP-3898631-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |