SCHEMBL2491150

SCHEMBL2491150

COC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 2/20 0.50
DPP8 Q6V1X1 2/20 0.50
DPP9 Q86TI2 2/20 0.50
DPP7 Q9UHL4 2/20 0.50
FAP Q12884 1/20 0.50
CA12 O43570 2/20 0.47
CA14 Q9ULX7 2/20 0.47
BIRC2 Q13490 1/20 0.43
TSHR P16473 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.41
TAS1R3 Q7RTX0 1/20 0.41
TAS1R1 Q7RTX1 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
ALDH1A1 P00352 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40
MAPT P10636 1/20 0.40
HSD17B10 Q99714 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7348800 1.00 DPP4 (0.50) DPP4DPP8DPP9DPP7FAP
Hydrochloric Acid SCHEMBL7324906 0.98 DPP4 (0.48) DPP4DPP8DPP9DPP7FAP
Hydrochloric Acid SCHEMBL7321497 0.98 DPP4 (0.48) DPP4DPP8DPP9DPP7FAP
SCHEMBL7354071 0.96 DPP4 (0.47) DPP4DPP8DPP9DPP7FAP
SCHEMBL7354079 0.96 DPP4 (0.47) DPP4DPP8DPP9DPP7FAP
SCHEMBL29466169 0.88 DPP4 (0.50) DPP4DPP8DPP9DPP7FAP
SCHEMBL13086357 0.86 CA12 (0.48) DPP4CA12CA14BIRC2TSHR
SCHEMBL19425794 0.85 DPP4 (0.47) DPP4DPP8DPP9DPP7FAP
Hydrochloric Acid SCHEMBL30698081 0.84 CA12 (0.47) DPP4CA12CA14BIRC2TSHR
SCHEMBL7613644 0.84 BIRC2 (0.45) CA12CA14BIRC2TSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0204775-A4 AMINO ACID AND PEPTIDE INHIBITORS OF HUMAN LEUCOCYTIC ELASTASE. UNIV TROBE (AU) 1989-10-04 EP claimed
EP-0204775-A1 AMINO ACID AND PEPTIDE INHIBITORS OF HUMAN LEUCOCYTIC ELASTASE AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) 1986-12-17 EP claimed
WO-1986003746-A1 AMINO ACID AND PEPTIDE INHIBITORS OF HUMAN LEUCOCYTIC ELASTASE LA TROBE UNIVERSITY (AU) 1986-07-03 WO claimed
EP-3439658-B1 SOLUBLE C5AR ANTAGONISTS CHEMOCENTRYX INC (US) 2021-11-24 EP disclosed
US-10329314-B2 Soluble C5aR antagonists CHEMOCENTRYX, INC. (US) 2019-06-25 US disclosed
US-20170283446-A1 SOLUBLE C5aR ANTAGONISTS CHEMOCENTRYX, INC. 2017-10-05 US disclosed
US-9227995-B2 Peptides Jacobsen, Øyvind (NO) 2016-01-05 US disclosed
US-9227995-B2 Peptides Jacobsen, Øyvind (NO) 2016-01-05 US disclosed
US-8389764-B2 Urea and sulfamide derivatives as inhibitors of TAFIa SANOFI (FR) 2013-03-05 US disclosed
US-20110263479-A1 Peptides UNIVERSITETET I OSLO (NO) 2011-10-27 US disclosed
US-20110263479-A1 Peptides UNIVERSITETET I OSLO (NO) 2011-10-27 US disclosed
EP-0594586-A1 HIV PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1994-05-04 EP disclosed
WO-1991010442-A1 HIV PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1991-07-25 WO disclosed
WO-1990005141-A1 AMINO ACID AND PEPTIDE INHIBITORS OF HUMAN LEUKOCYTIC ELASTASE AND COLLAGENASE AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) 1990-05-17 WO disclosed
CN-1039596-A Preparation method in conjunction with the peptide of retroviral Protease SMITHKLINE BECKMAN CORP (US) 1990-02-14 CN disclosed
WO-1990000399-A1 RETROVIRAL PROTEASE BINDING PEPTIDES SMITHKLINE BECKMAN CORPORATION (US) 1990-01-25 WO disclosed
EP-0352000-A2 Retroviral protease binding peptides SMITHKLINE BEECHAM CORPORATION (US) 1990-01-24 EP disclosed
EP-0204775-A4 AMINO ACID AND PEPTIDE INHIBITORS OF HUMAN LEUCOCYTIC ELASTASE. UNIV TROBE (AU) 1989-10-04 EP disclosed
EP-0204775-A1 AMINO ACID AND PEPTIDE INHIBITORS OF HUMAN LEUCOCYTIC ELASTASE AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED (AU) 1986-12-17 EP disclosed
WO-1986003746-A1 AMINO ACID AND PEPTIDE INHIBITORS OF HUMAN LEUCOCYTIC ELASTASE LA TROBE UNIVERSITY (AU) 1986-07-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170283446-A1 SOLUBLE C5aR ANTAGONISTS C5AR1, C3AR1, C5AR2 DPP4 1748/4885DPP8 1664/4885DPP9 1343/4885
US-20110263479-A1 Peptides VIP, NGLY1, NPPA DPP4 118/4885DPP8 125/4885DPP9 136/4885
US-10329314-B2 Soluble C5aR antagonists C5AR1, C3AR1, C5AR2 DPP4 1748/4885DPP8 1664/4885DPP9 1343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.