Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methyldopa. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.97 |
| ▸ | MAPT | P10636 | 6/20 | 0.97 |
| ▸ | BLM | P54132 | 5/20 | 0.97 |
| ▸ | HPGD | P15428 | 4/20 | 0.97 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.97 |
| ▸ | RECQL | P46063 | 4/20 | 0.97 |
| ▸ | POLB | P06746 | 3/20 | 0.97 |
| ▸ | GAA | P10253 | 3/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.97 |
| ▸ | APEX1 | P27695 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | USP2 | O75604 | 2/20 | 0.97 |
| ▸ | EGFR | P00533 | 2/20 | 0.97 |
| ▸ | FYN | P06241 | 2/20 | 0.97 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyldopa (Racemic) SCHEMBL259452 | 1.00 | KDM4E (0.97) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa (Racemic) SCHEMBL2494131 | 0.98 | KDM4E (0.94) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa SCHEMBL6825739 | 0.98 | KDM4E (0.94) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa SCHEMBL11448470 | 0.98 | KDM4E (0.94) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa SCHEMBL34003 | 0.98 | KDM4E (1.00) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa SCHEMBL29352376 | 0.98 | KDM4E (1.00) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa (Racemic) SCHEMBL196981 | 0.98 | KDM4E (1.00) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa SCHEMBL30176814 | 0.98 | KDM4E (1.00) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa SCHEMBL1172822 | 0.98 | KDM4E (1.00) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa SCHEMBL1321546 | 0.98 | KDM4E (1.00) | KDM4ETDP1HSD17B10MAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927028-B2 | Pharmaceutical composition containing coated, floating particles | JAGOTEC AG (CH) | 2015-01-06 | — | — | US | claimed |
| CN-104098860-A | Preparation method for polyvinylidene fluoride/poly-dopamine-coated graphene nanocomposite | UNIV SICHUAN | 2014-10-15 | — | — | CN | claimed |
| EP-1382331-B1 | A pharmaceutical tablet characterized by showing a high volume increase when coming into contact with biological fluids | JAGOTEC AG (CH) | 2011-10-26 | — | — | EP | claimed |
| US-20080317841-A1 | Pharmaceutical Composition Containing Coated, Floating Particles | JAGOTEC AG (CH) | 2008-12-25 | — | — | US | claimed |
| US-20080020041-A1 | Enteric Coated Compositions that Release Active Ingredient(s) in Gastric Fluid and Intestinal Fluid | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY | 2008-01-24 | — | — | US | claimed |
| EP-1835893-A1 | PHARMACEUTICAL COMPOSITION CONTAINING COATED, FLOATING PARTICLES | Jagotec AG (CH) | 2007-09-26 | — | — | EP | claimed |
| EP-1811975-A2 | ENTERIC COATED COMPOSITIONS THAT RELEASE ACTIVE INGREDIENT(S) IN GASTRIC FLUID AND INTESTINAL FLUID | The State of Oregon Acting by and (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006063858-A1 | PHARMACEUTICAL COMPOSITION CONTAINING COATED, FLOATING PARTICLES | JAGOTEC AG (CH) | 2006-06-22 | — | — | WO | claimed |
| WO-2006044202-A2 | ENTERIC COATED COMPOSITIONS THAT RELEASE ACTIVE INGREDIENT(S) IN GASTRIC FLUID AND INTESTINAL FLUID | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) | 2006-04-27 | — | — | WO | claimed |
| EP-0795324-B1 | A pharmaceutical tablet characterized by showing a high volume increase when coming into contact with biological fluids | JAGOTEC AG (CH) | 2004-04-21 | — | — | EP | claimed |
| EP-1382331-A1 | A pharmaceutical tablet characterized by a showing high volume increase when coming into contact with biological fluids | JAGOTEC AG (CH) | 2004-01-21 | — | — | EP | claimed |
| US-5780057-A | Pharmaceutical tablet characterized by a showing high volume increase when coming into contact with biological fluids | JAGOTEC AG (CH) | 1998-07-14 | — | — | US | claimed |
| EP-0795324-A2 | A pharmaceutical tablet characterized by a showing high volume increase when coming into contact with biological fluids | JAGOTEC AG (CH) | 1997-09-17 | — | — | EP | claimed |
| CN-1119434-A | Phenoxyphenylacetic acid derivatives | MERCK & CO INC (US) | 1996-03-27 | — | — | CN | claimed |
| CN-119731370-A | Method and system for coating a drug container, cleaning a drug container and checking a drug container for particles and defects | 二氧化硅医疗产品公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-114980869-B | Large-scale production of exosome mimics and uses thereof | 儿童医学中心公司 | 2024-08-27 | — | — | CN | disclosed |
| CN-117298254-A | CHOLIX toxin-derived fusion molecules for oral delivery of biologically active cargo | 应用分子转运公司 | 2023-12-29 | — | — | CN | disclosed |
| US-4038411-A | ANTIHYPERTENSIVE AMINO ACID ESTERS | MERCK & CO., INC. (US) | 1977-07-26 | — | — | US | disclosed |
| US-4016288-A | ANIMALS, A-HYDRAZINO-3,4-DIHYDROXY-PHENYL-PROPIONIC ACID WITH AN ALANINATE | MERCK & CO., INC. (US) | 1977-04-05 | — | — | US | disclosed |
| US-3983138-A | HYPOTENSIVES | MERCK & CO., INC. (US) | 1976-09-28 | — | — | US | disclosed |