Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methyldopa (Racemic). The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.94 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.94 |
| ▸ | MAPT | P10636 | 6/20 | 0.94 |
| ▸ | BLM | P54132 | 5/20 | 0.94 |
| ▸ | HPGD | P15428 | 4/20 | 0.94 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.94 |
| ▸ | RECQL | P46063 | 4/20 | 0.94 |
| ▸ | POLB | P06746 | 3/20 | 0.94 |
| ▸ | GAA | P10253 | 3/20 | 0.94 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.94 |
| ▸ | APEX1 | P27695 | 3/20 | 0.94 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.94 |
| ▸ | USP2 | O75604 | 2/20 | 0.94 |
| ▸ | EGFR | P00533 | 2/20 | 0.94 |
| ▸ | FYN | P06241 | 2/20 | 0.94 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyldopa SCHEMBL11448470 | 1.00 | KDM4E (0.94) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa SCHEMBL6825739 | 1.00 | KDM4E (0.94) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa (Racemic) SCHEMBL29013197 | 0.98 | KDM4E (0.97) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa SCHEMBL2491162 | 0.98 | KDM4E (0.97) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa SCHEMBL17747949 | 0.98 | KDM4E (0.97) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa (Racemic) SCHEMBL28059914 | 0.98 | KDM4E (0.97) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa (Racemic) SCHEMBL259452 | 0.98 | KDM4E (0.97) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa SCHEMBL27977941 | 0.98 | KDM4E (0.97) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa (Racemic) SCHEMBL196981 | 0.97 | KDM4E (1.00) | KDM4ETDP1HSD17B10MAPTBLM | |
| Methyldopa SCHEMBL1172822 | 0.97 | KDM4E (1.00) | KDM4ETDP1HSD17B10MAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4256108-A | Microporous-semipermeable laminated osmotic system | ALZA CORPORATION (US) | 1981-03-17 | — | — | US | claimed |
| EP-1817008-B1 | STABILIZED HME COMPOSITION WITH SMALL DRUG PARTICLES | UNIV TEXAS (US) | 2020-04-01 | — | — | EP | disclosed |
| US-9867786-B2 | Stabilized compositions containing alkaline labile drugs | AUXILIUM US HOLDINGS, LLC (US) | 2018-01-16 | — | — | US | disclosed |
| US-9730894-B2 | Stabilized HME composition with small drug particles | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-08-15 | — | — | US | disclosed |
| US-20170119669-A1 | STABILIZED HME COMPOSITION WITH SMALL DRUG PARTICLES | UNIV TEXAS (US) | 2017-05-04 | — | — | US | disclosed |
| EP-2010366-B1 | PROCESS FOR THE PREPARATION OF A HOT-MELT EXTRUDED LAMINATE | AUXILIUM INT HOLDINGS INC (US) | 2017-03-22 | — | — | EP | disclosed |
| EP-3141248-A1 | STABILIZED COMPOSITIONS CONTAINING ALKALINE LABILE DRUGS | Auxilium International Holdings, Inc. (US) | 2017-03-15 | — | — | EP | disclosed |
| US-9504658-B2 | Stabilized HME composition with small drug particles | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-11-29 | — | — | US | disclosed |
| EP-2010156-B1 | STABILIZED COMPOSITIONS CONTAINING ALKALINE LABILE DRUGS | AUXILIUM INT HOLDINGS INC (US) | 2016-11-16 | — | — | EP | disclosed |
| US-20160256405-A1 | STABILIZED COMPOSITIONS CONTAINING ALKALINE LABILE DRUGS | AUXILIUM US HOLDINGS, LLC. (US) | 2016-09-08 | — | — | US | disclosed |
| EP-0169105-B1 | CONTROLLED POROSITY OSMOTIC PUMP | MERCK & CO. INC. (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4968507-A | SUSTAINED RELEASE OF DRUG | MERCK & CO., INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0208617-B1 | CONTROLLED DRUG DEVICE AND PROCESS FOR CATALYSING THE EROSION OF AN ACID LABILE POLYMER | MERCK & CO. INC. (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4851228-A | Multiparticulate controlled porosity osmotic | MERCK & CO., INC. (US) | 1989-07-25 | — | — | US | disclosed |
| US-4780319-A | DRUG DELIVERY USING POLYORTHOESTERS COATINGS | MERCK & CO., INC. (US) | 1988-10-25 | — | — | US | disclosed |
| US-4673405-A | Osmotic system with instant drug availability | ALZA CORPORATION (US) | 1987-06-16 | — | — | US | disclosed |
| EP-0208617-A1 | Controlled drug device and process for catalysing the erosion of an acid labile polymer | MERCK & CO. INC. (US) | 1987-01-14 | — | — | EP | disclosed |
| US-4576604-A | Osmotic system with instant drug availability | ALZA CORPORATION (US) | 1986-03-18 | — | — | US | disclosed |
| EP-0169105-A2 | Controlled porosity osmotic pump | MERCK & CO. INC. (US) | 1986-01-22 | — | — | EP | disclosed |
| US-4256108-A | Microporous-semipermeable laminated osmotic system | ALZA CORPORATION (US) | 1981-03-17 | — | — | US | disclosed |