Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 4/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 4/20 | 0.37 |
| ▸ | TTK | P33981 | 4/20 | 0.37 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CDKL1 | Q00532 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123142 | 0.92 | PTK6 (0.39) | PTK6SYKTTKMAPKAPK5 | |
| SCHEMBL30168175 | 0.92 | PTK6 (0.39) | PTK6SYKTTKMAPKAPK5 | |
| SCHEMBL30168207 | 0.92 | PTK6 (0.39) | PTK2PTK6SYKTTKMAPKAPK5 | |
| SCHEMBL22123373 | 0.92 | PTK6 (0.39) | PTK2PTK6SYKTTKMAPKAPK5 | |
| SCHEMBL24870783 | 0.91 | TTK (0.37) | PTK6SYKTTKMAPKAPK5POLB | |
| Hydrochloric Acid SCHEMBL22124453 | 0.91 | PTK6 (0.39) | PTK6SYKTTKMAPKAPK5 | |
| SCHEMBL24940106 | 0.91 | SYK (0.44) | PTK6SYKTTKMAPKAPK5 | |
| Hydrochloric Acid SCHEMBL30386239 | 0.91 | PTK6 (0.39) | PTK6SYKTTKMAPKAPK5 | |
| SCHEMBL22124809 | 0.91 | PTK6 (0.37) | PTK6SYKTTKMAPKAPK5IDO1 | |
| Hydrochloric Acid SCHEMBL30349837 | 0.90 | SYK (0.43) | PTK6SYKTTKMAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230022724-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-26 | — | — | US | disclosed |
| US-20230017532-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230022724-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | MRPL21, O60361, MYD88 | PTK2 4182/4885PTK6 2201/4885SYK 992/4885 |
| US-20230017532-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | MRPL21, O60361, MYD88 | PTK2 4183/4885PTK6 2141/4885SYK 939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.