SCHEMBL24917588

SCHEMBL24917588

CCC(=O)O[C@H]1[C@@H](O)[C@](C)(c2ccc3c(N)ncnn23)O[C@@H]1COC(=O)CC(C)C

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 4/20 0.33
▸ CA1 P00915 4/20 0.33
▸ CA2 P00918 4/20 0.33
▸ CA9 Q16790 4/20 0.33
▸ CA14 Q9ULX7 4/20 0.33
▸ PRKD3 O94806 1/20 0.30
▸ PRKCG P05129 1/20 0.30
▸ PRKCB P05771 1/20 0.30
▸ PRKCA P17252 1/20 0.30
▸ PRKCH P24723 1/20 0.30
▸ PRKCI P41743 1/20 0.30
▸ PRKCE Q02156 1/20 0.30
▸ PRKCQ Q04759 1/20 0.30
▸ PRKCZ Q05513 1/20 0.30
▸ PRKCD Q05655 1/20 0.30
▸ PRKD1 Q15139 1/20 0.30
▸ RIPK1 Q13546 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24917123 0.96 CA12 (0.36) CA12CA1CA2CA9CA14
SCHEMBL24917156 0.93 CA12 (0.32) CA12CA1CA2CA9CA14
SCHEMBL24916799 0.93 CA12 (0.32) CA12CA1CA2CA9CA14
SCHEMBL25911801 0.91 CA12 (0.32) CA12CA1CA2CA9CA14
SCHEMBL24790488 0.91 CA12 (0.32) CA12CA1CA2CA9CA14
SCHEMBL24789411 0.90 CA12 (0.31) CA12CA1CA2CA9CA14
SCHEMBL24791782 0.90 RIPK1 (0.31) RIPK1
SCHEMBL24917064 0.90 PIK3CD (0.32) —
SCHEMBL24789413 0.90 CA12 (0.33) CA12CA1CA2CA9CA14
SCHEMBL25911739 0.89 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230233593-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS VenatoRx Pharmaceuticals, Inc. 2023-07-27 — — US disclosed
US-11638715-B2 Orally-bioavailable nucleoside analogs VenatoRx Pharmaceuticals, Inc. (US) 2023-05-02 — — US disclosed
US-20230024722-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS VenatoRx Pharmaceuticals, Inc. 2023-01-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230024722-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS SLC29A2, SLC29A1, PNP CA12 4247/4885CA1 4839/4885CA2 4634/4885
US-11638715-B2 Orally-bioavailable nucleoside analogs SLC29A2, SLC29A1, PNP CA12 4247/4885CA1 4839/4885CA2 4634/4885
US-20230233593-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS SLC29A2, SLC29A1, PNP CA12 4247/4885CA1 4839/4885CA2 4634/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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