Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.46 |
| ▸ | GSK3B | P49841 | 7/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | LATS1 | O95835 | 1/20 | 0.34 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743598 | 1.00 | GPR119 (0.46) | GPR119GSK3BCYP1A2CYP2D6GPBAR1 | |
| SCHEMBL3743594 | 1.00 | GPR119 (0.46) | GPR119GSK3BCYP1A2CYP2D6GPBAR1 | |
| SCHEMBL2491778 | 1.00 | GPR119 (0.46) | GPR119GSK3BCYP1A2CYP2D6GPBAR1 | |
| SCHEMBL2485633 | 0.89 | GSK3B (0.43) | GPR119GSK3BCYP1A2CYP2D6LATS1 | |
| SCHEMBL2485638 | 0.89 | GSK3B (0.43) | GPR119GSK3BCYP1A2CYP2D6LATS1 | |
| SCHEMBL2485634 | 0.89 | GSK3B (0.43) | GPR119GSK3BCYP1A2CYP2D6LATS1 | |
| SCHEMBL2488014 | 0.86 | GSK3B (0.41) | GPR119GSK3BCYP1A2CYP2D6LATS1 | |
| SCHEMBL2488012 | 0.86 | GSK3B (0.41) | GPR119GSK3BCYP1A2CYP2D6LATS1 | |
| SCHEMBL2488013 | 0.86 | GSK3B (0.41) | GPR119GSK3BCYP1A2CYP2D6LATS1 | |
| SCHEMBL2490497 | 0.85 | GSK3B (0.43) | GPR119GSK3BCYP1A2CYP2D6LATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057141-B1 | PYRIMIDONE COMPOUNDS AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2011-10-26 | — | — | EP | disclosed |