Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 9/20 | 0.45 |
| ▸ | GUSB | P08236 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.34 |
| ▸ | GLB1 | P16278 | 1/20 | 0.34 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24919793 | 0.84 | GBA1 (0.44) | GBA1GUSBGAALMNAMAN1B1 | |
| SCHEMBL14433368 | 0.84 | GBA1 (0.44) | GBA1GAA | |
| SCHEMBL22193283 | 0.79 | DNM1 (0.34) | GBA1LMNADNM1 | |
| SCHEMBL22871215 | 0.79 | DNM1 (0.34) | GBA1LMNADNM1 | |
| SCHEMBL22193291 | 0.79 | DNM1 (0.34) | GBA1LMNADNM1 | |
| SCHEMBL955176 | 0.77 | GBA1 (0.55) | GBA1GAAMAN1B1GLB1GBA2 | |
| SCHEMBL955173 | 0.77 | GBA1 (0.55) | GBA1GAAMAN1B1GLB1GBA2 | |
| SCHEMBL21912150 | 0.75 | DNM1 (0.41) | GBA1LMNADNM1 | |
| SCHEMBL21911258 | 0.75 | DNM1 (0.41) | GBA1LMNADNM1 | |
| SCHEMBL21725511 | 0.75 | DNM1 (0.41) | GBA1LMNADNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230024302-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230024302-A1 | 2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS | PIK3CA, PIK3CG, PIK3CD | GBA1 3240/4885GUSB 4763/4885GAA 2298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.