Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499912 | 0.78 | RXRA (0.35) | FLT3MAPK9 | |
| SCHEMBL16815659 | 0.78 | MKNK1 (0.48) | EIF2AK2MKNK1MKNK2ALDH1A1KDM4E | |
| SCHEMBL1231970 | 0.76 | KMT2A (0.49) | EIF2AK2MKNK1MKNK2KMT2ARECQL | |
| SCHEMBL2884302 | 0.75 | MAPK9 (0.44) | TNFEIF2AK2MKNK1MKNK2MEN1 | |
| SCHEMBL10225045 | 0.75 | MAPK1 (0.59) | TNFEIF2AK2MKNK1MKNK2MEN1 | |
| SCHEMBL18615429 | 0.73 | MKNK1 (0.48) | TNFEIF2AK2MKNK1MKNK2MEN1 | |
| SCHEMBL24921019 | 0.72 | MAPK1 (0.46) | MAPK1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL11306815 | 0.71 | MKNK1 (0.50) | EIF2AK2MKNK1MKNK2MEN1GAA | |
| SCHEMBL84065 | 0.71 | MAPK9 (0.48) | TNFEIF2AK2MKNK1MKNK2MEN1 | |
| SCHEMBL24921051 | 0.71 | EGFR (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |