Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.42 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23981902 | 0.84 | IRAK4 (0.46) | IRAK4PIM1MKNK1CHEK1CLK2 | |
| Hydrochloric Acid SCHEMBL31098638 | 0.83 | IRAK4 (0.45) | IRAK4PIM1MKNK1CHEK1CLK2 | |
| SCHEMBL30519807 | 0.79 | IRAK4 (0.50) | IRAK4PIM1MKNK1CHEK1CLK2 | |
| SCHEMBL29289920 | 0.78 | IRAK4 (0.47) | IRAK4PIM1MKNK1MKNK2CHEK1 | |
| SCHEMBL30625193 | 0.77 | CCR1 (0.52) | IRAK4PIM1CHEK1CLK2CLK1 | |
| SCHEMBL12269967 | 0.77 | CCR1 (0.52) | IRAK4PIM1CHEK1CLK2CLK1 | |
| SCHEMBL23541648 | 0.76 | IRAK4 (0.41) | IRAK4PIM1MKNK1CLK2CLK1 | |
| SCHEMBL30625166 | 0.76 | IRAK4 (0.53) | IRAK4PIM1MKNK1CHEK1CLK2 | |
| SCHEMBL25794156 | 0.76 | ASIC3 (0.52) | IRAK4PIM1CHEK1CLK2CLK1 | |
| SCHEMBL3508335 | 0.76 | PIM1 (0.51) | IRAK4PIM1CHEK1CLK2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115677667-A | Bifunctional chimera heterocyclic compound and application thereof as androgen receptor degrading agent | 海创药业股份有限公司 | 2023-02-03 | — | — | CN | disclosed |
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |